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KMID : 0351619750160010295
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Kyungpook Medical Journal
1975 Volume.16 No. 1 p.295 ~ p.302
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The effect of subconjunctival Depo-Medrol injection s on ocular tension and aqueous humor dynamics
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Abstract
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In order to observe the changes of the intraocular pressure and the coefficent of a aqueous outflow facility with subconjunctival injection of Depo-Medrol(Upjohn Co.) in human and rabbit, the serial electronic tonometry was performed. In the human, the :Follow-up checks were performed on 1st, 5th, 10th, and from 40 to 50th day after the subconjuoctival injection and in the rabbits, on i:he 5th, 15th, 25th, 50th, and 118th day after the injection.
The mean value of the intraocular pressure and the coei´ficient of aqueous outflow facilit}* in the normal rabbits were 23.3mmHg and 0.23G respectively, In the rabbits, the effects of subconjunctival Depo-Medrol injections on aqueous outflow facility were vague and irregular except far the Po/c Ratio changes. In the rabbit group B which were injected with 20mg. of Depo-medrol, it showed a significant decrease in Po/c Ratio on the 5th day but the subsequent increase was much lesser Than group A.
The human eyes showed a slight increase in the coefficent of aqueous outflow facility on first day after the subconjunctival injection of Depo-medrol and s:hotved subsequently significant decrease thereafter.
There were no remarkable changes of intra-ocular pressure in human group and so, the Fo/c ra tia appeared to be increased along- the follow-up courses except for the first day´s riinute decreas.
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KEYWORD
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